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If insurers were expected to absorb the difference, that could be a steep recurring expense
Homocysteine and MTHFR Mutations
doi: 10.1038/s41586-022-05266-z 21 McIntyreR
(Source: PMC / JAMA Surgery, 2025) An NYU Langone Study Found a Five-Fold Difference A separate head-to-head real-world study from NYU Langone Health and NYC Health + Hospitals found patients who underwent bariatric surgery lost an average of 58 pounds after two years , compared with 12 pounds for patients on a GLP-1 prescription for at least six months roughly five times more weight loss with surgery
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Groups requiring caution or avoidance: Active severe depression or suicidal thoughts History of bipolar disorder or psychosis Current or previous eating disorders Adolescents (specialist supervision required) Patients with complex psychiatric conditions requiring coordinated care Regarding pregnancy, semaglutide should be discontinued at least 2 months before a planned pregnancy
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